Fit and compare nonlinear mixed-effects models in differential
equations with flexible dosing information commonly seen in pharmacokinetics
and pharmacodynamics (Almquist, Leander, and Jirstrand 2015
<doi:10.1007/s10928-015-9409-1>). Differential equation solving is
by compiled C code provided in the 'rxode2' package
(Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
| Version: |
2.0.6 |
| Depends: |
R (≥ 4.0), nlmixr2data |
| Imports: |
Rcpp (≥ 0.12.3), lbfgsb3c, dparser, methods, rex, minqa, Matrix, n1qn1 (≥ 6.0.1-10), rxode2 (≥ 1.0.0), nlme, magrittr, backports, symengine |
| LinkingTo: |
dparser (≥ 0.1.8), rxode2 (≥ 1.0.0), RcppEigen (≥
0.3.3.3.0), lbfgsb3c, Rcpp, BH, StanHeaders (≥ 2.18.0), RcppArmadillo (≥ 0.5.600.2.0) |
| Suggests: |
Rvmmin, broom.mixed, crayon, knitr, data.table, devtools, digest, dplyr, lotri, nloptr, pkgdown, rmarkdown, testthat, ucminf, generics, tibble, checkmate, cli, qs, covr, vpc, withr, xgxr |
| Published: |
2022-05-12 |
| Author: |
Matthew Fidler 
[aut, cre],
Yuan Xiong [aut],
Rik Schoemaker
[aut],
Justin Wilkins
[aut],
Wenping Wang [aut],
Robert Leary [ctb],
Mason McComb
[ctb],
Vipul Mann [aut],
Mirjam Trame [ctb],
Mahmoud Abdelwahab [ctb],
Teun Post [ctb],
Richard Hooijmaijers [aut],
Hadley Wickham [ctb],
Dirk Eddelbuettel [cph],
Johannes Pfeifer [ctb],
Robert B. Schnabel [ctb],
Elizabeth Eskow [ctb],
Emmanuelle Comets [ctb],
Audrey Lavenu [ctb],
Marc Lavielle [ctb],
David Ardia [cph],
Katharine Mullen [cph],
Ben Goodrich [ctb] |
| Maintainer: |
Matthew Fidler <matthew.fidler at gmail.com> |
| License: |
GPL (≥ 3) |
| URL: |
https://github.com/nlmixr2/nlmixr2est |
| NeedsCompilation: |
yes |
| Language: |
en-US |
| Citation: |
nlmixr2est citation info |
| Materials: |
NEWS |
| CRAN checks: |
nlmixr2est results |