nlmixr2est: Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 2.0.6
Depends: R (≥ 4.0), nlmixr2data
Imports: Rcpp (≥ 0.12.3), lbfgsb3c, dparser, methods, rex, minqa, Matrix, n1qn1 (≥ 6.0.1-10), rxode2 (≥ 1.0.0), nlme, magrittr, backports, symengine
LinkingTo: dparser (≥ 0.1.8), rxode2 (≥ 1.0.0), RcppEigen (≥, lbfgsb3c, Rcpp, BH, StanHeaders (≥ 2.18.0), RcppArmadillo (≥ 0.5.600.2.0)
Suggests: Rvmmin, broom.mixed, crayon, knitr, data.table, devtools, digest, dplyr, lotri, nloptr, pkgdown, rmarkdown, testthat, ucminf, generics, tibble, checkmate, cli, qs, covr, vpc, withr, xgxr
Published: 2022-05-12
Author: Matthew Fidler ORCID iD [aut, cre], Yuan Xiong [aut], Rik Schoemaker ORCID iD [aut], Justin Wilkins ORCID iD [aut], Wenping Wang [aut], Robert Leary [ctb], Mason McComb ORCID iD [ctb], Vipul Mann [aut], Mirjam Trame [ctb], Mahmoud Abdelwahab [ctb], Teun Post [ctb], Richard Hooijmaijers [aut], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Katharine Mullen [cph], Ben Goodrich [ctb]
Maintainer: Matthew Fidler <matthew.fidler at>
License: GPL (≥ 3)
NeedsCompilation: yes
Language: en-US
Citation: nlmixr2est citation info
Materials: NEWS
CRAN checks: nlmixr2est results


Reference manual: nlmixr2est.pdf


Package source: nlmixr2est_2.0.6.tar.gz
Windows binaries: r-devel:, r-release: not available, r-oldrel:
macOS binaries: r-release (arm64): nlmixr2est_2.0.6.tgz, r-oldrel (arm64): nlmixr2est_2.0.6.tgz, r-release (x86_64): nlmixr2est_2.0.6.tgz, r-oldrel (x86_64): nlmixr2est_2.0.6.tgz


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