Keyboard: Bayesian Designs for Early Phase Clinical Trials
We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials.
| Version: |
0.1.0 |
| Depends: |
R (≥ 3.4.0), Rcpp (≥ 0.12.0), methods |
| Imports: |
Iso |
| Suggests: |
epade |
| Published: |
2020-07-07 |
| Author: |
Hongying Sun, Li Tang, and Haitao Pan |
| Maintainer: |
Hongying Sun <hongyingsun1101 at gmail.com> |
| License: |
GPL-2 |
| NeedsCompilation: |
no |
| In views: |
ClinicalTrials |
| CRAN checks: |
Keyboard results |
Documentation:
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