Keyboard: Bayesian Designs for Early Phase Clinical Trials

We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials.

Version: 0.1.0
Depends: R (≥ 3.4.0), Rcpp (≥ 0.12.0), methods
Imports: Iso
Suggests: epade
Published: 2020-07-07
Author: Hongying Sun, Li Tang, and Haitao Pan
Maintainer: Hongying Sun <hongyingsun1101 at>
License: GPL-2
NeedsCompilation: no
In views: ClinicalTrials
CRAN checks: Keyboard results


Reference manual: Keyboard.pdf


Package source: Keyboard_0.1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): Keyboard_0.1.0.tgz, r-oldrel (arm64): Keyboard_0.1.0.tgz, r-release (x86_64): Keyboard_0.1.0.tgz, r-oldrel (x86_64): Keyboard_0.1.0.tgz


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