Bifurcating autoregressive (BAR) models are commonly used to model binary tree-structured data that appear in many applications, most famously cell-lineage applications. The BAR model is an extension of the autoregressive (AR) model where each line of descent considers an AR process with the modification that the observations on the two sibling cells who share the same parent are correlated. In practice, the BAR model is used to explain the progression of single-cell proliferation. The goal of the `bifurcatingr`

package is to provide a collection of functions that can be used for analyzing bifurcating autoregressive data. The package implements the least squares estimation of bifurcating autoregressive models of any order, p, BAR(p), and allows for executing several types of bias correction on the least-squares estimators of the autoregressive parameters. Currently, the bias correction methods supported include bootstrap (single, double, and fast-double) bias correction and linear-bias-function-based bias correction. The library also contains functions for generating and plotting bifurcating autoregressive data from any BAR(p) model.

You can install the released version of `bifurcatingr`

from CRAN with:

```
install.packages("bifurcatingr")
#> Installing package into '/private/var/folders/7g/qtr08lf57lg62btzppl4cf4w0000gn/T/Rtmp1aFm9S/temp_libpath475cf58b299'
#> (as 'lib' is unspecified)
#> Warning: package 'bifurcatingr' is not available for this version of R
#>
#> A version of this package for your version of R might be available elsewhere,
#> see the ideas at
#> https://cran.r-project.org/doc/manuals/r-patched/R-admin.html#Installing-packages
```

This is a basic example which shows you how to use `bifurcatingr`

to fit a bifurcating autoregressive model to the `ecoli`

dataset which contains the lifetimes of lineage E. coli cells.

Loading the `bifurcatingr`

library and the `ecoli`

dataset:

```
library(bifurcatingr)
data("ecoli")
```

Fitting a BAR(p=1) model to the `ecoli`

dataset:

```
bfa.ls(ecoli$lifetime, p = 1, conf = TRUE, conf.level = 0.95,
p.value = TRUE, cov.matrix = TRUE)
#> $coef
#> Intercept X_[t/2]
#> [1,] 17.61658 0.355198
#>
#> $conf
#> 2.5% 97.5%
#> Intercept 4.0722831 31.1608852
#> X_[t/2] -0.1654543 0.8758503
#>
#> $p.value
#> Intercept X_[t/2]
#> [1,] 0.01079535 0.181183
#>
#> $error.cor
#> [1] 0.5836975
#>
#> $cov.matrix
#> [,1] [,2]
#> [1,] 1480.39874 -56.147524
#> [2,] -56.14752 2.187566
```