adpss: Design and Analysis of Locally or Globally Efficient Adaptive
Provides the functions for planning and conducting a
clinical trial with adaptive sample size determination. Maximal statistical
efficiency will be exploited even when dramatic or multiple adaptations
are made. Such a trial consists of adaptive determination of sample size
at an interim analysis and implementation of frequentist statistical test at the
interim and final analysis with a prefixed significance level. The required
assumptions for the stage-wise test statistics are independent and stationary
increments and normality. Predetermination of adaptation rule is not required.
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