Helps a clinical trial team discuss the clinical goals of a well-defined biomarker with a diagnostic, staging, prognostic, or predictive purpose. From this discussion will come a statistical plan for a (non-randomized) validation trial. Both prospective and retrospective trials are supported. In a specific focused discussion, investigators should determine the range of "discomfort" for the NNT, number needed to treat. The meaning of the discomfort range, [NNTlower, NNTupper], is that within this range most physicians would feel discomfort either in treating or withholding treatment. A pair of NNT values bracketing that range, NNTpos and NNTneg, become the targets of the study's design. If the trial can demonstrate that a positive biomarker test yields an NNT less than NNTlower, and that a negative biomarker test yields an NNT less than NNTlower, then the biomarker may be useful for patients. A highlight of the package is visualization of a "contra-Bayes" theorem, which produces criteria for retrospective case-controls studies.
|Imports:||shiny, xtable, stringr, magrittr, mvbutils|
|Suggests:||testthat (≥ 0.8.1), knitr (≥ 1.6), rmarkdown, ggplot2, plyr|
|Maintainer:||Roger Day <day01 at pitt.edu>|
|CRAN checks:||NNTbiomarker results|
The biomarker crisis
Using the NNTbiomarker package
The debugTools component
|Windows binaries:||r-devel: NNTbiomarker_0.29.11.zip, r-release: NNTbiomarker_0.29.11.zip, r-oldrel: NNTbiomarker_0.29.11.zip|
|macOS binaries:||r-release (arm64): NNTbiomarker_0.29.11.tgz, r-release (x86_64): NNTbiomarker_0.29.11.tgz, r-oldrel: NNTbiomarker_0.29.11.tgz|
|Old sources:||NNTbiomarker archive|
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