DRviaSPCN: Drug Repurposing in Cancer via a Subpathway Crosstalk Network

A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

Version: 0.1.2
Depends: R (≥ 3.6)
Imports: ChemmineR, GSVA, clusterProfiler, graphics, igraph, pheatmap, rvest, xml2, stats
Suggests: rmarkdown, knitr, DT
Published: 2022-03-03
Author: Junwei Han [aut, cre, cph], Jiashuo Wu [aut]
Maintainer: Junwei Han <hanjunwei1981 at 163.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: DRviaSPCN results

Documentation:

Reference manual: DRviaSPCN.pdf
Vignettes: DRviaSPCN

Downloads:

Package source: DRviaSPCN_0.1.2.tar.gz
Windows binaries: r-devel: DRviaSPCN_0.1.2.zip, r-release: DRviaSPCN_0.1.2.zip, r-oldrel: DRviaSPCN_0.1.2.zip
macOS binaries: r-release (arm64): DRviaSPCN_0.1.2.tgz, r-release (x86_64): DRviaSPCN_0.1.2.tgz, r-oldrel: not available
Old sources: DRviaSPCN archive

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