PriorCD: Prioritizing Cancer Drugs for Interested Cancer
Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.
| Version: |
0.1.0 |
| Depends: |
R (≥ 2.10) |
| Imports: |
igraph, dplyr, ROCR, visNetwork |
| Suggests: |
knitr, rmarkdown |
| Published: |
2019-02-24 |
| Author: |
Junwei Han [ctb, cre],
Jieyi Di [aut],
Baotong Zheng [aut] |
| Maintainer: |
Junwei Han <hanjunwei1981 at 163.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
no |
| CRAN checks: |
PriorCD results |
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