GEint: Misspecified Models for Gene-Environment Interaction
First major functionality is to compute the bias in misspecified linear gene-environment interaction models. The most
generalized function for this objective is GE_bias(). However GE_bias() requires specification of many
higher order moments of covariates in the model. If users are unsure about how to calculate/estimate
these higher order moments, it may be easier to use GE_bias_normal_squaredmis(). This function places
many more assumptions on the covariates (most notably that they are all jointly generated from a multivariate
normal distribution) and is thus able to automatically calculate many of the higher order moments automatically,
necessitating only that the user specify some covariances. There are also functions to solve for the bias
through simulation and non-linear equation solvers, these can be used to check your work. Second major functionality
is to implement the Bootstrap Inference with Correct Sandwich (BICS) testing procedure, which we have found to provide better finite-sample
performance than other inference procedures for testing GxE interaction. More details on these functions
are available in Sun, Carroll, Christiani, and Lin, "Testing for Gene-Environment Interaction Under Exposure Misspecification"
(In Revision).
| Version: |
0.1.5 |
| Imports: |
mvtnorm, bindata, nleqslv, pracma, speedglm, rje, geepack, stats |
| Suggests: |
knitr, rmarkdown, testthat |
| Published: |
2019-01-15 |
| Author: |
Ryan Sun [aut, cre],
Richard Barfield [ctb] |
| Maintainer: |
Ryan Sun <ryansun.work at gmail.com> |
| License: |
GPL-3 |
| NeedsCompilation: |
no |
| CRAN checks: |
GEint results |
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