Functions, data and user interfaces for performing physiologically based pharmacokinetic ('PBPK') modeling, in-vitro-to-in-vivo Extrapolation ('IVIVE') and exposure estimation. Also contains user interfaces to run models from the 'httk' package. Taken together these provide an easy to use and powerful modeling tool that can be used for all steps along the source-to-outcome continuum.All the analysis tools in the package are run as interactive applications. Check package help for more information. Refer to the manuscript 'Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling' <doi:10.1016/j.comtox.2019.100115> for more information on the models and algorithms used in the package. More information on PBPK modeling itself can be found in the book 'Physiologically Based Pharmacokinetic Modeling: Science and Applications' by Reddy et al <doi:10.1002/0471478768>.
| Version: | 1.1.0 |
| Depends: | R (≥ 3.6.0) |
| Imports: | shiny, ggplot2, shinyBS, shinyWidgets, miniUI, shinydashboard, rstudioapi, shinythemes, rhandsontable, deSolve, truncdist, reshape2, dplyr, readxl, gdata, devtools, RSQLite, formatR, plotly, magrittr, sqldf, utils, stats, DT, shinyjs, V8, httk, NonCompart, stringr, doParallel, foreach, pracma, shinybusy, data.table, tidyr, shinyalert, shinyFiles, officer, DiagrammeR, DiagrammeRsvg, rsvg, devEMF |
| Suggests: | testthat, shinytest, rmarkdown, knitr |
| Published: | 2020-11-04 |
| Author: | Salil Pendse [aut], Kevin Bronson [aut], Jeremy Fitzpatrick [aut, cre], Patrick McMullen [ctb], ScitoVation, LLC [cph] |
| Maintainer: | Jeremy Fitzpatrick <jfitzpatrick at scitovation.com> |
| BugReports: | https://github.com/ScitoVation/plethem/issues/ |
| License: | MIT + file LICENSE |
| URL: | https://github.com/ScitoVation/plethem/ |
| NeedsCompilation: | yes |
| Materials: | README |
| CRAN checks: | plethem results |
| Reference manual: | plethem.pdf |
| Vignettes: |
Modeling Using PLETHEM |
| Package source: | plethem_1.1.0.tar.gz |
| Windows binaries: | r-devel: plethem_1.1.0.zip, r-release: plethem_1.1.0.zip, r-oldrel: plethem_1.1.0.zip |
| macOS binaries: | r-release: plethem_1.1.0.tgz, r-oldrel: plethem_1.1.0.tgz |
| Old sources: | plethem archive |
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