Facilitates simulation from hierarchical, ordinary differential equation (ODE) based models typically employed in drug development. A model specification file is created consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects. A dosing event engine allows interventions (bolus and infusion) to be managed separately from the model code. Differential equations are solved with the 'DLSODA' routine in 'ODEPACK' ().

Documentation

Manual: mrgsolve.pdf
Vignette: None available.

Maintainer: Kyle T Baron <kyleb at metrumrg.com>

Author(s): Kyle T Baron*, Alan C Hindmarsh*, Linda R Petzold*, Bill Gillespie*, Charles Margossian*, Devin Pastoor*, Metrum Research Group LLC*

Install package and any missing dependencies by running this line in your R console:

install.packages("mrgsolve")

Depends R (>= 3.1.2), methods
Imports Rcpp(>=0.12.3), dplyr(>=0.5.0), magrittr(>=1.5), lazyeval(>=0.1.10), RcppArmadillo(>=0.5.600.2.0), tibble(>=1.2)
Suggests lattice, testthat, XML, rmarkdown
Enhances
Linking to Rcpp(>=0.12.1), RcppArmadillo(>=0.5.600.2.0), BH
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Package mrgsolve
Materials
URL https://github.com/metrumresearchgroup/mrgsolve
Task Views
Version 0.8.6
Published 2017-03-16
License GPL (>= 2)
BugReports https://github.com/metrumresearchgroup/mrgsolve/issues
SystemRequirements
NeedsCompilation yes
Citation
CRAN checks mrgsolve check results
Package source mrgsolve_0.8.6.tar.gz