Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) ] Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values. The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.

Documentation

Manual: LEANR.pdf
Vignettes:

Maintainer: Frederik Gwinner <frederik.gwinner at gmail.com>

Author(s): Frederik Gwinner

Install package and any missing dependencies by running this line in your R console:

install.packages("LEANR")

Depends R (>= 2.14), igraph(>=0.7.1), foreach(>=1.4.2)
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Package LEANR
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Version 1.4.9
Published 2016-11-12
License GPL-3
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NeedsCompilation no
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CRAN checks LEANR check results
Package source LEANR_1.4.9.tar.gz